Article
CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions.
Gastroenterology - 1 Jun 2007
Allez Matthieu, Tieng Vannary, Nakazawa Atsushi, Treton Xavier, Pacault Vincent, Dulphy Nicolas, Caillat-Zucman Sophie, Paul Pascale, Gornet Jean-Marc, Douay Corinne, Ravet Sophie, Tamouza Ryad, Charron Dominique, Lémann Marc, Mayer Lloyd, Toubert Antoine
Abstract excerpt
BACKGROUND & AIMS: Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithel...
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