Article
Mucosal-associated invariant T cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity.
International immunology - 7 Nov 2023
Brauns Steffen, Marquardt Isabel, Thon Cosima, Frentzel Sarah, Jakob Josefine, Färber Jacqueline, Philipsen Lars, Jänsch Lothar, Link Alexander, Bruder Dunja
Abstract excerpt
Mucosal-associated invariant T (MAIT) cells are innate-like T cells mainly found in the mucosa and peripheral blood. We have recently demonstrated that Clostridioides difficile activates MAIT cells in vitro. However, their role in the pathogenesis of C. difficile infection (CDI) in human patients remains elusive to date. In this study, we performed comprehensive immunophenotyping of MAIT cells derived from CDI...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.