Article
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2007
Luke May M, Kane John P, Liu Dongming M, Rowland Charles M, Shiffman Dov, Cassano June, Catanese Joseph J, Pullinger Clive R, Leong Diane U, Arellano Andre R, Tong Carmen H, Movsesyan Irina, Naya-Vigne Josephina, Noordhof Curtis, Feric Nicole T, Malloy Mary J, Topol Eric J, Koschinsky Marlys L, Devlin James J, Ellis Stephen G
Abstract excerpt
OBJECTIVES: The purpose of this study was to identify genetic variants associated with severe coronary artery disease (CAD). METHODS AND RESULTS: We used 3 case-control studies of white subjects whose severity of CAD was assessed by angiography. The first 2 studies were used to generate hypotheses that were then tested in the third study. We tested 12,077 putative functional single nucleotide polymorphisms (SNPs)...
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