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C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1.

Nature cell biology - 1 May 2007

Wang Xiaochen, Wang Jin, Gengyo-Ando Keiko, Gu Lichuan, Sun Chun-Ling, Yang Chonglin, Shi Yong, Kobayashi Tetsuo, Shi Yigong, Mitani Shohei, Xie Xiao-Song, Xue Ding

Abstract excerpt

Externalization of phosphatidylserine, which is normally restricted to the inner leaflet of plasma membrane, is a hallmark of mammalian apoptosis. It is not known what activates and mediates the phosphatidylserine externalization process in apoptotic cells. Here, we report the development of an annexin V-based phosphatidylserine labelling method and show that a majority of apoptotic germ cells in Caenorhabditis...

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PMID: 17401362
DOI: 10.1038/ncb1574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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