Article
Generation of T cell clones binding F(ab')2 fragments of the idiotypic immunoglobulin in patients with monoclonal gammopathy.
Cancer immunology, immunotherapy : CII - 1 Jan 1991
Osterborg A, Masucci M, Bergenbrant S, Holm G, Lefvert A K, Mellstedt H
Abstract excerpt
Lymphocytes from two patients with multiple myeloma stage I and one patient with monoclonal gammopathy of undetermined significance were found to proliferate specifically in response to low concentrations of F(ab')2 fragments of the autologous M component. T cell clones isolated from repeatedly stimulated cultures bound specifically the autologous idiotype and proliferated after addition of soluble idiotype and...
Topics
- Cell Division
- Cells, Cultured
- Clone Cells
- Humans
- Immunoglobulin Fab Fragments
- Immunoglobulin Idiotypes
- Leukocytes, Mononuclear
- Lymphocyte Activation
- Multiple Myeloma
- Paraproteinemias