Establishment of idiotype bearing B-lymphocyte clones from a patient with monoclonal gammopathy.

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Article

Establishment of idiotype bearing B-lymphocyte clones from a patient with monoclonal gammopathy.

Blood - 15 Nov 1991

Osterborg A, Steinitz M, Lewin N, Bergenbrant S, Holm G, Lefvert A K, Mellstedt H

Abstract excerpt

B-lymphocyte clones bearing an idiotypic Ig structure, which could also be found on the serum M-component, have been isolated from peripheral blood of a patient with monoclonal gammopathy (MG) using an immune-rosetting technique and limiting dilution. The majority of the cells had the surface phenotype id+/CD19+/CD20+/CD21+ or id+/CD19+/CD20+/CD21-. Some of the clones originated from spontaneous outgrowth of...

Topics

Antibodies, Monoclonal
Antigens, CD
B-Lymphocytes
Blotting, Southern
Cell Line
Clone Cells
DNA
Female
Fluorescent Antibody Technique
Gene Rearrangement
Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin Fab Fragments

Immunoglobulin G

Immunoglobulin Heavy Chains

Immunoglobulin Idiotypes

Isoelectric Focusing

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 1824258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1824258-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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