Article
Establishment of idiotype bearing B-lymphocyte clones from a patient with monoclonal gammopathy.
Blood - 15 Nov 1991
Osterborg A, Steinitz M, Lewin N, Bergenbrant S, Holm G, Lefvert A K, Mellstedt H
Abstract excerpt
B-lymphocyte clones bearing an idiotypic Ig structure, which could also be found on the serum M-component, have been isolated from peripheral blood of a patient with monoclonal gammopathy (MG) using an immune-rosetting technique and limiting dilution. The majority of the cells had the surface phenotype id+/CD19+/CD20+/CD21+ or id+/CD19+/CD20+/CD21-. Some of the clones originated from spontaneous outgrowth of...
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