Insights into the role of heritable genetic variation in the pharmacokinetics and pharmacodynamics of anticancer drugs.

Abstract excerpt

Pharmacogenetics in oncology will ideally allow oncologists to individualise therapy based on a genetic test result. Severe toxicity and clinically significant underdosing may be avoided, whereas predicted non-responders can be offered alternative therapy. This manuscript gives an overview of heritable variants in the genes of nine enzymes or pathways that have been studied most extensively in anticancer...

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