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Article

C/EBPδ regulates cell cycle and self-renewal of human limbal stem cells

11 Jun 2007

Abstract excerpt

Human limbal stem cells produce transit amplifying progenitors that migrate centripetally to regenerate the corneal epithelium. Coexpression of CCAAT enhancer binding protein delta (C/EBPdelta), Bmi1, and DeltaNp63alpha identifies mitotically quiescent limbal stem cells, which generate holoclones in culture. Upon corneal injury, a fraction of these cells switches off C/EBPdelta and Bmi1, proliferates, and...

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PMID: 17562792
DOI: 10.1083/jcb.200703003

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