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Article

Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell.

Journal of cellular and molecular medicine - 1 Aug 2008

Kawakita Tetsuya, Shimmura Shigeto, Hornia Armand, Higa Kazunari, Tseng Scheffer C G

Abstract excerpt

The limbal region of the adult cornea contains stem cells which are ultimately responsible for regeneration of the corneal epithelium during wound repair. However, primarily-isolated murine corneal/limbal epithelial cells rapidly senesce on plastic in a serum-free low [Ca(2+)] medium, suggesting only transit amplifying cells are promoted. We developed a novel expansion method by seeding at a low cell density...

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Identifiers

PMID: 18318692
DOI: 10.1111/j.1582-4934.2008.00297.x
PMCID: PMC3225011

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