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Article

Isoforms of ΔNp63 and the migration of ocular limbal cells in human corneal regeneration

27 Jun 2005

Abstract excerpt

The p63 gene generates transactivating and N-terminally truncated transcripts (DeltaNp63) initiated by different promoters. Alternative splicing gives rise to three different C termini, designated alpha, beta, and gamma. In the ocular epithelium, the corneal stem cells, which are segregated in the basal layer of the limbus, contain the alpha isoform but not beta or gamma. Holoclones derived from the limbus are...

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PMID: 15983386
DOI: 10.1073/pnas.0503437102

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