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Article

The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin Complex

9 Jun 2007

Abstract excerpt

Tankyrase1 is a multifunctional poly(ADP-ribose) polymerase that can localize to telomeres through its interaction with the shelterin component TRF1. Tankyrase1 poly(ADP-ribosyl)ates TRF1 in vitro, and its nuclear overexpression leads to loss of TRF1 and telomere elongation, suggesting that tankyrase1 is a positive regulator of telomere length. In agreement with this proposal, we show that tankyrase1 RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17561506
DOI: 10.1074/jbc.m702620200

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Related research

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The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin ComplexPMID 17561506Read ↗

Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human TelomeresSemantic proximity Read ↗

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Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and CappingSemantic proximity Read ↗

Identification of a Tankyrase-binding Motif Shared by IRAP, TAB182, and Human TRF1 but Not Mouse TRF1Semantic proximity Read ↗

Tankyrase promotes telomere elongation in human cellsSemantic proximity Read ↗

Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.Semantic proximity Read ↗

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.Semantic proximity Read ↗

The telomeric PARP, tankyrases, as targets for cancer therapySemantic proximity Read ↗

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length RegulationSemantic proximity Read ↗

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.Semantic proximity Read ↗

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradationSemantic proximity Read ↗

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