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Article

Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice

1 Mar 2006

Abstract excerpt

Telomere length and function are crucial factors that determine the capacity for cell proliferation and survival, mediate cellular senescence, and play a role in malignant transformation in eukaryotic systems. The telomere length of a specific mammalian species is maintained within a given range by the action of telomerase and telomere-associated proteins. TRF1 is a telomere-associated protein that inhibits...

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Share to DNA Repair Mechanisms
Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 16507984
DOI: 10.1128/mcb.26.6.2037-2043.2006

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Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient MicePMID 16507984Read ↗

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.Semantic proximity Read ↗

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Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human TelomeresSemantic proximity Read ↗

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Modeling premature aging syndromes with the telomerase knockout mouse.Semantic proximity Read ↗

Tankyrase promotes telomere elongation in human cellsSemantic proximity Read ↗

Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease.Semantic proximity Read ↗

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Identification of a Tankyrase-binding Motif Shared by IRAP, TAB182, and Human TRF1 but Not Mouse TRF1Semantic proximity Read ↗

Establishment of conditional knockout alleles for the gene encoding the regulator of telomere length (RTEL).Semantic proximity Read ↗

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