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Article

The telomeric PARP, tankyrases, as targets for cancer therapy

17 Jan 2006

Abstract excerpt

The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target.

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Share to DNA Repair Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16421589
DOI: 10.1038/sj.bjc.6602951

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Related research

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Research trail→

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The telomeric PARP, tankyrases, as targets for cancer therapyPMID 16421589Read ↗

Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human TelomeresSemantic proximity Read ↗

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Research Advances in the Role of the Poly ADP Ribose Polymerase Family in CancerSemantic proximity Read ↗

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High-Throughput RNAi Screening Reveals Novel Regulators of TelomeraseSemantic proximity Read ↗

Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancerSemantic proximity Read ↗

Crossroads of telomere biology and anticancer drug discoverySemantic proximity Read ↗

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human CellsSemantic proximity Read ↗

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other DiseasesSemantic proximity Read ↗

Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and CappingSemantic proximity Read ↗

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