Article
Lack of TNFalpha mRNA expression in cervical cancer is not associated with loss of heterozygosity at 6p21.3, inactivating mutations or promoter methylation.
Molecular immunology - 1 Jan 2008
Kloth Judith N, Gorter Arko, ter Haar Natalja, Corver Willem E, Jordanova Ekaterina S, Kenter Gemma G, Fleuren Gert Jan
Abstract excerpt
Infection with oncogenic human papillomavirus (HPV) is considered to be the major etiologic event for cervical cancer. Tumor necrosis factor alpha (TNFalpha), a proinflammatory cytokine, may be involved in orchestrating an antitumor immune response against human papillomavirus expressing cervical cancer cells. Hence, loss of TNFalpha could be advantageous for tumor cells to escape immune clearance. The aim of our...
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