Article
Absence of BRAF mutation in pheochromocytoma and paraganglioma.
Neoplasma - 1 Jan 2000
Vosecka T, Vicha A, Zelinka T, Jencova P, Pacak K, Duskova J, Benes J, Guha A, Stanek L, Kohoutova M, Musil Z
Abstract excerpt
Pheochromocytomas and Paragangliomas (PHEO/PARA) are rare endocrine tumors originating from the adrenal medulla. More than 20 genes are involved in the tumorigenesis of these tumors, but a substantial part of the causative genetic events remains unexplained. A recent study has reported the presence of the activating BRAF V600E mutation in PCC, suggesting a role for BRAF activation in tumor development. Other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.