Genetics of Pheochromocytomas and Paragangliomas Determine the Therapeutical Approach.

Abstract excerpt

Pheochromocytomas and paragangliomas are the most heritable endocrine tumors. In addition to the inherited mutation other driver mutations have also been identified in tumor tissues. All these genetic alterations are clustered in distinct groups which determine the pathomechanisms. Most of these tumors are benign and their surgical removal will resolve patient management. However, 5-15% of them are malignant and...

Topics

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• Mutation
• Adrenal and Paraganglionic Tumors
• Adrenal Gland Neoplasms
• Carcinogenesis
• Genetic Predisposition to Disease