Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas.

Endocrine - 1 Feb 2017

Borsari Simona, Pardi Elena, Pellegata Natalia S, Lee Misu, Saponaro Federica, Torregrossa Liborio, Basolo Fulvio, Paltrinieri Elena, Zatelli Maria Chiara, Materazzi Gabriele, Miccoli Paolo, Marcocci Claudio, Cetani Filomena

Abstract excerpt

MEN1 is the main gene responsible for tumorigenesis of syndromic and sporadic primary hyperparathyroidism (PHPT). Germline mutations of the CDKN1B/p27Kip gene have been associated with multiple endocrine tumors in rats and humans. To evaluate the involvement of the CDKN1B gene and its relationship with MEN1 in sporadic PHPT, we carried out sequencing and loss of heterozygosity analyses of the CDKN1B gene in 147...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MEN1 gene

Share to Hyperparathyroidism, Primary

Share to Immunohistochemistry

Share to Mutation

Share to Parathyroid Neoplasms

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 27038812
DOI: 10.1007/s12020-016-0941-6

Genes

MEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas.PMID 27038812Read ↗

Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas.Semantic proximity Read ↗

Germline CDKN1B/p27Kip1 Mutation in Multiple Endocrine NeoplasiaSemantic proximity Read ↗

Novel somatic MEN1 gene alterations in sporadic primary hyperparathyroidism and correlation with clinical characteristics.Semantic proximity Read ↗

MEN1 intragenic deletions may represent the most prevalent somatic event in sporadic primary hyperparathyroidism.Semantic proximity Read ↗

The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other than<i>p27</i><i>Kip1</i>MutationsSemantic proximity Read ↗

A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.Semantic proximity Read ↗

Functional characterization of a CDKN1B mutation in a Sardinian kindred with multiple endocrine neoplasia type 4Semantic proximity Read ↗

A heterozygous frameshift mutation in exon 1 of CDKN1B gene in a patient affected by MEN4 syndromeSemantic proximity Read ↗

Multiple endocrine neoplasia type 4.Semantic proximity Read ↗

MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism.Semantic proximity Read ↗

Germline CDKN1B variant type and site are associated with phenotype in MEN4.Semantic proximity Read ↗

p27Kip1 and Tumors: Characterization of CDKN1B Variants Identified in MEN4 and Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.