Article
Radiation-induced transgenerational alterations in genome stability and DNA damage.
Oncogene - 30 Nov 2006
Barber R C, Hickenbotham P, Hatch T, Kelly D, Topchiy N, Almeida G M, Jones G D D, Johnson G E, Parry J M, Rothkamm K, Dubrova Y E
Abstract excerpt
Mutation induction in directly exposed cells is currently regarded as the main component of the genetic risk of ionizing radiation for humans. However, recent data on the transgenerational increases in mutation rates in the offspring of irradiated parents indicate that the genetic risk could be greater than predicted previously. Here, we have analysed transgenerational changes in mutation rates and DNA damage in...
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