Article
Simple models of genomic variation in human SNP density.
BMC genomics - 6 Jun 2007
Sainudiin Raazesh, Clark Andrew G, Durrett Richard T
Abstract excerpt
BACKGROUND: Descriptive hierarchical Poisson models and population-genetic coalescent mixture models are used to describe the observed variation in single-nucleotide polymorphism (SNP) density from samples of size two across the human genome. RESULTS: Using empirical estimates of recombination rate across the human genome and the observed SNP density distribution, we produce a maximum likelihood estimate of the...
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