Methods for human demographic inference using haplotype patterns from genomewide single-nucleotide polymorphism data.

Abstract excerpt

We propose a novel approximate-likelihood method to fit demographic models to human genomewide single-nucleotide polymorphism (SNP) data. We divide the genome into windows of constant genetic map width and then tabulate the number of distinct haplotypes and the frequency of the most common haplotype for each window. We summarize the data by the genomewide joint distribution of these two statistics-termed the HCN...

Topics

• Computer Simulation
• Emigration and Immigration
• Genetic Variation
• Genome, Human
• Genome-Wide Association Study
• Haplotypes
• Humans
• Models, Genetic
• Polymorphism, Single Nucleotide