Article
Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties.
The Journal of rheumatology - 1 Jun 2007
Bokarewa Maria, Abrahamson Magnus, Levshin Nikolay, Egesten Arne, Grubb Anders, Dahlberg Leif, Tarkowski Andrej
Abstract excerpt
OBJECTIVE: To assess the interaction between cystatin C (CysC) and serum amyloid A protein (SAA). METHODS: Levels of CysC and SAA and antibodies against these proteins were assessed in the paired blood and synovial fluid (SF) samples of 90 patients with rheumatoid arthritis (RA). Age and sex matched individuals having normal iohexol clearance (n = 90) and SF following joint trauma (n = 40) were used as controls....
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