Article
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.
Molecular pathology : MP - 1 Dec 1999
Huh C G, Håkansson K, Nathanson C M, Thorgeirsson U P, Jonsson N, Grubb A, Abrahamson M, Karlsson S
Abstract excerpt
AIMS: Increased or altered activities of cysteine proteases have been implicated in serious human disorders such as cancer, rheumatoid arthritis, sepsis, and osteoporosis. To improve the current knowledge of the regulatory role of a major mammalian cysteine protease inhibitor, cystatin C, in such disease processes, a cystatin C deficient mouse was generated and characterized. METHODS: The mouse cystatin C gene...
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