Article
Intermediate filaments: from cell architecture to nanomechanics.
Nature reviews. Molecular cell biology - 1 Jul 2007
Herrmann Harald, Bär Harald, Kreplak Laurent, Strelkov Sergei V, Aebi Ueli
Abstract excerpt
Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties...
Topics
- Amino Acid Sequence
- Animals
- Biomechanical Phenomena
- Cell Nucleus
- Cytoplasm
- Cytoskeleton
- Dimerization
- Humans
- Intermediate Filaments
- Lamins
- Models, Biological