Article
"IF-pathies": a broad spectrum of intermediate filament-associated diseases.
The Journal of clinical investigation - 1 Jul 2009
Omary M Bishr
Abstract excerpt
Intermediate filaments (IFs) are encoded by the largest gene family among the three major cytoskeletal protein groups. Unique IF compliments are expressed in selective cell types, and this expression is reflected in their involvement, upon mutation, as a cause of or predisposition to more than 80 human tissue-specific diseases. This Review Series covers diseases and functional and structural aspects pertaining to...
Topics
- Humans
- Intermediate Filament Proteins
- Intermediate Filaments
- Mutation