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Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.

Journal of medical genetics - 1 Jun 2007

Chinnery P F, Mowbray C, Patel S K, Elson J L, Sampson M, Hitman G A, McCarthy M I, Hattersley A T, Walker M

Abstract excerpt

Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogenic mutations of mitochondrial DNA (mtDNA) can cause diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising the possibility that genetic variants of mtDNA alter the risk of developing the disorder. Recent studies have produced conflicting results. By studying 897 UK cases of type 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17551080
DOI: 10.1136/jmg.2007.048876
PMCID: PMC2740896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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