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Article

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

23 Nov 2009

Abstract excerpt

Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques (RMs) is associated with chronic immune activation. To elucidate the mechanisms underlying this intriguing phenotype, we used high-density oligonucleotide microarrays to longitudinally assess host...

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PMID: 19959874
DOI: 10.1172/jci40115

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