Article
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.
Blood - 15 Jan 2009
Paiardini Mirko, Cervasi Barbara, Engram Jessica C, Gordon Shari N, Klatt Nichole R, Muthukumar Alagarraju, Else James, Mittler Robert S, Staprans Silvija I, Sodora Donald L, Silvestri Guido
Abstract excerpt
Bone marrow (BM) is the key hematopoietic organ in mammals and is involved in the homeostatic proliferation of memory CD8(+) T cells. Here we expanded on our previous observation that BM is a preferential site for T-cell proliferation in simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despite high viremia. We found high levels of mature T-cell proliferation,...
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