Article
Fluoroquinolone resistance in invasive Streptococcus pyogenes isolates due to spontaneous mutation and horizontal gene transfer.
Antimicrobial agents and chemotherapy - 1 Mar 2006
Pletz M W R, McGee L, Van Beneden C A, Petit S, Bardsley M, Barlow M, Klugman K P
Abstract excerpt
Fluoroquinolone resistance in Streptococcus pyogenes has been described only anecdotally. In this study we describe two invasive ciprofloxacin-resistant S. pyogenes isolates (ciprofloxacin MICs, 8 mg/liter), one of which shows evidence of interspecies recombination. The quinolone resistance-deter...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- Chi-Square Distribution
- Ciprofloxacin
- DNA, Bacterial
- Drug Resistance, Bacterial
- Female
- Fluoroquinolones
- Follow-Up Studies
- Gene Transfer, Horizontal
- Humans
- Male