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Article

Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1.

Oncogene - 4 Mar 2004

Jinnin Masatoshi, Ihn Hironobu, Asano Yoshihide, Yamane Kenichi, Trojanowska Maria, Tamaki Kunihiko

Abstract excerpt

In cultured human dermal fibroblasts, transforming growth factor (TGF)-beta induced the mRNA expression of tenascin-C (TN-C). The molecular mechanism(s) underlying this process is not presently understood. In this study, we performed serial 5' deletion and a transient transfection analysis to define a region in the TN-C promoter mediating the inducible responsiveness to TGF-beta. This region contains an atypical...

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PMID: 15001984
DOI: 10.1038/sj.onc.1207064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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