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Article

JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV).

Leukemia research - 1 Jan 2009

Mustjoki Satu, Borze Ioana, Lasho Terra L, Alitalo Riitta, Pardanani Animesh, Knuutila Sakari, Juvonen Eeva

Abstract excerpt

The in vitro cultures of erythroid (BFU-E) and megakaryocytic (CFU-Meg) progenitors have been useful diagnostic tools in myeloproliferative disorders (MPD). However, after the discovery of the JAK2V617F mutation, their diagnostic role has been uncertain. In this single-centre retrospective study we analyzed JAK2V617F mutation in 58 ET and 42 PV patients diagnosed according to WHO criteria and compared the results...

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Source

Identifiers

PMID: 18760472
DOI: 10.1016/j.leukres.2008.07.008

Genes

JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV).PMID 18760472Read ↗

JAK2V617F mutation and endogenous erythroid colony formation in patients with polycythaemia vera.Semantic proximity Read ↗

The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients.Semantic proximity Read ↗

[Evaluation of V617F mutation of JAK2 in negative chromosome Philadelphia chronic myeloproliferative disorders].Semantic proximity Read ↗

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemiaSemantic proximity Read ↗

Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies.Semantic proximity Read ↗

In vitro expansion of erythroid progenitors from polycythemia vera patients leads to decrease in JAK2 V617F allele.Semantic proximity Read ↗

Familial essential thrombocythemia with spontaneous megakaryocyte colony formation and acquired JAK2 mutations.Semantic proximity Read ↗

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone.Semantic proximity Read ↗

Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.Semantic proximity Read ↗

In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm.Semantic proximity Read ↗

Circulating megakaryocyte progenitors in myeloproliferative disorders are hypersensitive to interleukin‐3Semantic proximity Read ↗

Extending Jak2V617F and MplW515 Mutation Analysis to Single Hematopoietic Colonies and B and T LymphocytesSemantic proximity Read ↗

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