Article
Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.
Blood - 1 Jan 1999
Taksin A L, Couedic J P, Dusanter-Fourt I, Massé A, Giraudier S, Katz A, Wendling F, Vainchenker W, Casadevall N, Debili N
Abstract excerpt
Essential thrombocythemia (ET) and idiopathic myelofibrosis (PMF) are two myeloproliferative diseases characterized by a marked megakaryocytic (MK) involvement. The pathogenesis of these two diseases is unknown. Recently it has been shown that overexpression of Mpl-ligand (Mpl-L) in mice induces...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD34
- Autocrine Communication
- Cell Division
- Cell Line
- Cell-Free System
- Cells, Cultured
- Child
- Female
- Humans
- Male
- Megakaryocytes
- Middle Aged
- Mutation