Article
Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time.
British journal of haematology - 1 Dec 2006
Lasho Terra L, Pardanani Animesh, McClure Rebecca F, Mesa Ruben A, Levine Ross L, Gilliland D Gary, Tefferi Ayalew
Abstract excerpt
MPLW515L/K and JAK2V617F can co-exist in myelofibrosis with myeloid metaplasia (MMM). The chronology of clonal emergence was studied in three such cases using serially stored bone marrow. At diagnosis, a major MPL515 mutant clone was accompanied by a minor JAK2V617F clone in all three instances. At 25 time points over a period of 4-8 years, allele burden fluctuated but remained high for MPLW515L/K and low for...
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