Article
Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms.
Experimental hematology - 1 Oct 2009
Wang Xiaoli, LeBlanc Amanda, Gruenstein Steven, Xu Mingjiang, Mascarenhas John, Panzera Brenda, Wisch Nathaniel, Parker Charles, Goldberg Judith D, Prchal Josef, Hoffman Ronald, Najfeld Vesna
Abstract excerpt
OBJECTIVE: JAK2V617F occurs in approximately 93% of patients with polycythemia vera and approximately 50% of patients with either primary myelofibrosis or essential thrombocythemia. Chromosomal abnormalities are detected in 50% of patients with primary myelofibrosis, 29% with polycythemia vera, and 8% to 10% with essential thrombocythemia. The relationship between the presence of such chromosomal abnormalities...
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