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Article

A NOS1 gene polymorphism associated with asthma and specific immunoglobulin E response to mite allergens in a Colombian population.

International archives of allergy and immunology - 1 Jan 2007

Martínez B, Barrios K, Vergara C, Mercado D, Jiménez S, Gusmão L, Caraballo L

Abstract excerpt

BACKGROUND: Nitric oxide (NO) is involved in asthma pathogenesis and is synthesized by three isoforms of NO synthase, one of them encoded by NOS1 gene. The CA-repeat and the C5266T SNP in NOS1 exon 29 have been associated with asthma and IgE levels. We thought to test the association of asthma and asthma-related phenotypes with the exon 29 CA-repeat and the C5266T SNP in a Colombian population sample. METHODS:...

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Source

Identifiers

PMID: 17536218
DOI: 10.1159/000103221

Genes

NOS1

Variants

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