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Article

Tuning lambda6-85 towards downhill folding at its melting temperature.

Journal of molecular biology - 13 Jul 2007

Liu Feng, Gruebele Martin

Abstract excerpt

The five-helix bundle lambda6-85* is a fast two-state folder. Several stabilized mutants have been reported to fold kinetically near-downhill or downhill. These mutants undergo a transition to two-state folding kinetics when heated. It has been suggested that this transition is caused by increased hydrophobicity at higher temperature. Here we investigate two histidine-containing mutants of lambda6-85* to see if a...

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Identifiers

PMID: 17532338
DOI: 10.1016/j.jmb.2007.04.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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