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Article

Slowing down downhill folding: a three-probe study.

Biophysical journal - 8 Jul 2009

Kim Seung Joong, Matsumura Yoshitaka, Dumont Charles, Kihara Hiroshi, Gruebele Martin

Abstract excerpt

The mutant Tyr22Trp/Glu33Tyr/Gly46Ala/Gly48Ala of lambda repressor fragment lambda(6-85) was previously assigned as an incipient downhill folder. We slow down its folding in a cryogenic water-ethylene-glycol solvent (-18 to -28 degrees C). The refolding kinetics are probed by small-angle x-ray scattering, circular dichroism, and fluorescence to measure the radius of gyration, the average secondary structure...

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Identifiers

PMID: 19580767
DOI: 10.1016/j.bpj.2009.04.041
PMCID: PMC2711359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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