The fast and the slow: folding and trapping of λ6-85.

Abstract excerpt

Molecular dynamics simulations combining many microsecond trajectories have recently predicted that a very fast folding protein like lambda repressor fragment λ(6-85) D14A could have a slow millisecond kinetic phase. We investigated this possibility by detecting temperature-jump relaxation to 5 ms. While λ(6-85) D14A has no significant slow phase, two even more stable mutants do. A slow phase of λ(6-85) D14A does...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacteriophage lambda
• Share to Molecular Dynamics Simulation
• Share to Protein Denaturation