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Article

Site-specific methionine sulfoxide formation is the structural basis of chromatographic heterogeneity of apolipoproteins A-I, C-II, and C-III.

Journal of lipid research - 1 Sept 1991

von Eckardstein A, Walter M, Holz H, Benninghoven A, Assmann G

Abstract excerpt

ApoA-I and apoC-II are eluted in two isoforms and apoC-III2 is eluted in three isoforms by reversed phase high performance liquid chromatography (HPLC). The structural basis of these nongenetic heterogeneities was unravelled using HPLC of proteolytic peptides and time-of-flight secondary ion mass spectrometry (TOF-SIMS). In apoA-I, the chromatographic microheterogeneity was caused by the formation of methionine...

Topics

Amino Acid Sequence
Apolipoprotein A-I
Apolipoprotein C-II
Apolipoprotein C-III
Apolipoproteins C
Chromatography, High Pressure Liquid
Humans
Mass Spectrometry
Methionine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Mutation

Oxidation-Reduction

Peptide Fragments

Source

Identifiers

PMID: 1753217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1753217-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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