Article
On the relation between promoter divergence and gene expression evolution.
Molecular systems biology - 1 Jan 2008
Tirosh Itay, Weinberger Adina, Bezalel Dana, Kaganovich Mark, Barkai Naama
Abstract excerpt
Recent studies have characterized significant differences in the cis-regulatory sequences of related organisms, but the impact of these differences on gene expression remains largely unexplored. Here, we show that most previously identified differences in transcription factor (TF)-binding sequences of yeasts and mammals have no detectable effect on gene expression, suggesting that compensatory mechanisms allow...
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