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Article

Transforming Growth Factor-β1 Represses E-Cadherin Production via<i>Slug</i>Expression in Lens Epithelial Cells

25 May 2007

Abstract excerpt

PURPOSE: TGFbeta is a potent candidate for epithelial-mesenchymal transition (EMT) during the development of anterior polar cataracts in the human lens. The Snail superfamily is involved in EMT through the repression of E-cadherin production. This study was conducted to determine whether the Snail gene family is activated in the process of TGFbeta1-induced EMT and how TGFbeta1 regulates the expression of this...

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PMID: 17525203
DOI: 10.1167/iovs.06-0639

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