Article
Selection, hitchhiking and disequilibrium analysis at three linked loci with application to HLA data.
Genetics - 1 Nov 1991
Robinson W P, Cambon-Thomsen A, Borot N, Klitz W, Thomson G
Abstract excerpt
The HLA system has been extensively studied from an evolutionary perspective. Although it is clear that selection has acted on the genes in the HLA complex, the nature of this selection has yet to be fully clarified. A study of constrained disequilibrium values is presented that is applicable to HLA and other less polymorphic systems with three or more linked loci, with the purpose of identifying selection...
Topics
- Alleles
- Gene Frequency
- Genes, MHC Class I
- Genes, MHC Class II
- Genetic Linkage
- Genetics, Population
- HLA Antigens
- Haplotypes
- Humans
- Major Histocompatibility Complex
- Models, Theoretical