Article
Constrained disequilibrium values and hitchhiking in a three-locus system.
Genetics - 1 Nov 1998
Grote M N, Klitz W, Thomson G
Abstract excerpt
Positive selection on a new mutant allele can increase the frequencies of closely linked alleles (through hitchhiking), as well as create linkage disequilibrium between them. Because this disequilibrium is induced by the selected allele, one may be able to identify loci under selection by measuring the influence of a candidate locus on pairwise disequilibrium values at nearby loci. The constrained disequilibrium...
Topics
- Alleles
- Computer Simulation
- Gene Frequency
- Genetic Linkage
- Genome, Human
- Humans
- Models, Genetic
- Models, Theoretical