Article
Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus
19 Mar 2018
Abstract excerpt
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris (PV) and pemphigus foliaceus (PF) which are mainly caused by autoantibodies against desmoglein (Dsg) 1 and 3. Keratin alterations are a structural hallmark in pemphigus pathogenesis and correlate with loss of...
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