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Article

The redox-switch domain of Hsp33 functions as dual stress sensor.

Nature structural & molecular biology - 1 Jun 2007

Ilbert Marianne, Horst Janina, Ahrens Sebastian, Winter Jeannette, Graf Paul C F, Lilie Hauke, Jakob Ursula

Abstract excerpt

The redox-regulated chaperone Hsp33 is specifically activated upon exposure of cells to peroxide stress at elevated temperatures. Here we show that Hsp33 harbors two interdependent stress-sensing regions located in the C-terminal redox-switch domain of Hsp33: a zinc center sensing peroxide stress...

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Identifiers

PMID: 17515905
DOI: 10.1038/nsmb1244
PMCID: PMC2782886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17515905-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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