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Article

Zinc-mediated Reversible Multimerization of Hsp31 Enhances the Activity of Holding Chaperone.

Journal of molecular biology - 8 Jun 2018

Kim Jihong, Choi Dongwook, Cha So-Young, Oh Young-Mee, Hwang Eunha, Park Chankyu, Ryu Kyoung-Seok

Abstract excerpt

Hsp31 protein, belonging to the DJ-1/ThiJ/PfpI superfamily, increases the survival of Escherichia coli under various stresses. While it was reported as a holding chaperone, Hsp31 was also shown to exhibit the glyoxalase III activity in subsequent study. Here, we describe our finding that Hsp31 undergoes a Zn+2-mediated multimerization (HMWZinc), resulting in an enhanced chaperone activity. Furthermore, it was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29709570
DOI: 10.1016/j.jmb.2018.04.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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