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Article

How to flip the (redox) switch.

Cell - 27 Nov 2002

Georgiou George

Abstract excerpt

Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12464172
DOI: 10.1016/s0092-8674(02)01165-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How to flip the (redox) switch.PMID 12464172Read ↗

OxyR: a molecular code for redox-related signaling.Semantic proximity Read ↗

Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status.Semantic proximity Read ↗

Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.Semantic proximity Read ↗

A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxideSemantic proximity Read ↗

Chemically targeting the redox switch in AP1 transcription factor ΔFOSBSemantic proximity Read ↗

Redox flow as an instrument of gene regulation.Semantic proximity Read ↗

OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.Semantic proximity Read ↗

Free-radical-induced mutation vs redox regulation: costs and benefits of genes in organelles.Semantic proximity Read ↗

Yap1: a DNA damage responder in Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular mechanism of oxidative stress perception by the Orp1 protein.Semantic proximity Read ↗

Modulating Protein Function through Genetically Encoded Oxidative ChemistrySemantic proximity Read ↗

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamicsSemantic proximity Read ↗

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