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Article

Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jun 2007

Weppler Sherry A, Li Younan, Dubois Ludwig, Lieuwes Natasja, Jutten Barry, Lambin Philippe, Wouters Bradly G, Lammering Guido

Abstract excerpt

BACKGROUND AND PURPOSE: EGFRvIII has been described to function as an oncoprotein with constitutive activation promoting neoplastic transformation and tumorigenicity. The present study was undertaken to test whether EGFRvIII also contributes to hypoxia tolerance. MATERIAL AND METHODS: The human glioma cell line U373 was genetically modified to stably express EGFRvIII. Western blotting and immunohistochemistry...

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Identifiers

PMID: 17512071
DOI: 10.1016/j.radonc.2007.04.025

Genes

EGFR

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