Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2004

Lammering Guido, Hewit Theodore H, Holmes Mathew, Valerie Kristoffer, Hawkins William, Lin Peck-Sun, Mikkelsen Ross B, Schmidt-Ullrich Rupert K

Abstract excerpt

PURPOSE: The commonly expressed variant epidermal growth factor receptor (EGFR), the type III EGFR variant (EGFRvIII), functions as an oncoprotein promoting neoplastic transformation and tumorigenicity. The role of EGFRvIII in cellular responses to genotoxic stress, such as ionizing radiation, is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Glioma

Share to Mice, Nude

Share to Radiation, Ionizing

Share to Tyrosine

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 15475464
DOI: 10.1158/1078-0432.CCR-04-0393

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15475464-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity.PMID 15475464Read ↗

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.Semantic proximity Read ↗

ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells.Semantic proximity Read ↗

Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance.Semantic proximity Read ↗

Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme.Semantic proximity Read ↗

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cellsSemantic proximity Read ↗

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in GlioblastomaSemantic proximity Read ↗

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.Semantic proximity Read ↗

The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme.Semantic proximity Read ↗

A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 statusSemantic proximity Read ↗

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment.Semantic proximity Read ↗

Inhibition of Hsp90: A Multitarget Approach to RadiosensitizationSemantic proximity Read ↗

Adenovirus-mediatedp53 gene transfer suppresses growth of human glioblastoma cellsin vitro andin vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.