Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

Abstract excerpt

Mice devoid of PrP are resistant to scrapie and fail to replicate the agent. Introduction of transgenes expressing PrP into such mice restores susceptibility to scrapie. We find that truncated PrP devoid of the five copper binding octarepeats still sustains scrapie infection; however, incubation times are longer and prion titers and protease-resistant PrP are about 30-fold lower than in wild-type mice....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Brain Chemistry
• Share to Brain Tissue Transplantation