Article
In search of TP53 mutational hot spots for Li-Fraumeni syndrome in Asian populations.
Tropical medicine & international health : TM & IH - 1 Nov 2021
Lo Piccolo Luca, Jantrapirom Salinee, Moonmuang Sutpirat, Teeyakasem Pimpisa, Pasena Arnat, Suksakit Pathacha, Charoenkwan Pimlak, Pruksakorn Dumnoensun, Koonrungsesomboon Nut
Abstract excerpt
OBJECTIVE: Germline mutations of the TP53 tumour suppressor gene are the only known cause of the hereditary autosomal disorder called Li-Fraumeni syndrome (LFS). However, little information is available about TP53 pathogenic variants in Asian LFS patients, making it difficult to provide precise genetic counselling with regard to long-term cancer risk. We conducted a systematic review to gather relevant...
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